Sep 13, 2015; Glendale, AZ, USA; New Orleans Saints quarterback Drew Brees (9) reacts against the Arizona Cardinals at University of Phoenix Stadium. Mandatory Credit: Mark J. Rebilas-USA TODAY Sports
Tampa Bay Buccaneers at New Orleans Saints (-11.5)
Which team wants to lose the most? At home, Drew Brees will tear apart the Buccaneers defense and poor Jamies Winston won’t be able to keep up. His turnovers will be costly.
Pick: New Orleans 44, Tampa Bay 24
San Francisco 49ers at Pittsburgh Steelers (-5.5)
The Steelers’ offense moved the football well against the Patriots without the end product enough. Even without Le’Veon Bell and Martavis Bryant, they have enough firepower to get past the 49ers, who are coming off an impressive win in Week 1.
Pick: Pittsburgh 21, San Francisco 14
St. Louis Rams (-3.5) at Washington Redskins
This St. Louis defense is for real, and there is enough talent on offense to win games. The Rams can be a force at home and typically struggle on the road, but against the lowly Redskins, they will be too strong on both sides of the ball.
Pick: St. Louis 24, Washington 6
New England Patriots at Buffalo Bills (EVEN)
Does someone else want to make this pick for me? This is too tough to call. Over the past two seasons, the Bills have shutdown Aaron Rodgers, Peyton Manning and now Andrew Luck. Tom Brady didn’t play in Buffalo last season. On the other hand, the Patriots’ offense was rolling against the Steelers with Brady’s suspension nullified. Rex Ryan always plays New England hard, and I think he pulls it off.
Pick: Buffalo 21, New England 20
Next: Late games and primetime